Aumentos de sono rem induzido pelo estresse: influência da prolactina, do peptídeo do lóbulo intermediário tipo corticotrofina (clip) e da serotonina
Palavras-chave:
Estresse, Sono, Sono REM, Hormônios, Serotonina.Resumo
Considerando que expressão do sono REM (sono paradoxal ou sono dos sonhos) como um fator de resilência ao estresse, revisão tem como objetivo apontar alguns mecanismos neuroendocrinológicos e neuroquímicos envolvidos neste processo. Eventos estressantes, dependendo de sua natureza, tendem provocar aumento de sono REM durante o sono. O sono dos sonhos tem um papel importante no processamento mnemônico, inclusive o de caráter emocional. Prejuízos na expressão do sono REM após eventos estressantes tendem a prejudicar a evocação e/ou elaboração destas memórias, podendo levar a alguns quadros patológicos, como distúrbios de ansiedade e ao transtorno do estresse pós-traumático. Vários trabalhos demonstram que a prolactina, o CLIP (peptídeo do lóbulo intermediário tipo corticotrofina ou ACTH18-39) e a serotonina e podem estar envolvidos na regulação da expressão do sono REM após eventos estressantes.
Palavras-chaves: Estresse, Sono, Sono REM, Hormônios, Serotonina.
Abstract
Considering that REM sleep (rapid eyes movement sleep or dream sleep) expression as a resilience factor to stress, this review aims to highlight some neuroendocrine and neurochemical mechanisms involved in this process. Stressful events, depending on their nature, tend to cause REM sleep increases. Dream sleep plays an important role in mnemonic processing, including those of emotional character. Losses in REM sleep expression after stressful events tend to undermine the evocation and/or preparation of these memories, leading to some pathological conditions such as anxiety and posttraumatic stress disorder (PTSD). Several studies showed that prolactin, CLIP (corticotropin-like intermediate lobe peptide or ACTH18-39) and serotonin and may be involved in regulating the REM sleep expression of after stressful events.
Keywords: Stress, Sleep, REM sleep, Hormones, Serotonin.
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