Alterações do sistema imunológico relacionadas ao envelhecimento e suas consequências
Palavras-chave:
Imunossenescência, Envelhecimento, Sistema ImunológicoResumo
As alterações do sistema imunológico relacionadas ao envelhecimento são denominadas de imunossenescência. Essas alterações ocorrem tanto na imunidade inata quanto na imunidade adaptativa, e implicam em uma série de consequências clínicas aos idosos. O estudo da imunossenescência ajuda a entender porque os idosos são mais propensos a desenvolver muitas doenças e a enfatizar a importância dos cuidados a esses pacientes. Nesta breve revisão encontram-se as alterações imunológicas mais importantes relativas ao idoso e suas possíveis consequências clínicas.
Palavras-chave: Imunossenescência, Envelhecimento, Sistema Imunológico
Abstract
The aging-related alterations of the immune system are called immunosenescence. These alterations occur both in the innate and the adaptative immunity, and imply in a series of clinical consequences for the elderly. The study of immunosenescence helps to understand why aged people are more prone to develop many diseases and to stress the importance of care of these patients. In this brief review one can find the most important immunological alterations related to the elderly and their possible clinical consequences.
Keywords: Immunosenescence, Aging, Immune System
Referências
BAUER, M., et al. The Role of Stress Factors during Aging
of the Immune System. Annals of the New York Academy of
Sciences, v. 1153, p. 139-152, 2009.
BRUNNER, S. et al. Persistent viral infections and immune
aging. Ageing Research Reviews, v. 10, n. 3, p. 362-369,
DORRINGTON, M. G.; BOWDISH, D. M. Immunosenescence
and novel vaccination strategies for the elderly.
Frontiers in Immunology, v. 4, n. 171, p. 1-10, -2014.
FRANCESCHI, C. et al. The immunology of exceptional
individuals: the lesson of centenarians. Immunology Today,
v. 16, n. 1, p. 12-16, 1995.
GINALDI, L. et al. Immunological changes in the elderly.
Aging clinical and Experimental Research, v.11, n. 5, p.
-286, 1999a.
GINALDI, L. et al. The immune system in the elderly: I.
Specific Humoral Immunity. Immunologic Research, v.
, n. 2, p. 101-118, 1999b.
GINALDI, L. et al. The immune system in the elderly: III.
Inate Immunity. Immunologic Research, v. 20, n. 2, p. 117-
, 1999c.
GINALDI, L. et al. Immunosenescence and infectious
diseases. Microbes and Infections, v. 3, n. 10, p. 851-857,
GIRARD, T. D.; ELY, E. W. Bacteremia and sepsis in older
adults. Clinics in Geriatric Medicine, v. 23, n. 3, p. 633-
, 2007.
HAKIM, F. T. et al. Aging, immunity and cancer. Current
Opinion in Immunology, v. 16, n. 2, p. 151-156, 2004.
HAKIM, F. T.; GRESS, R. E. Immunosenescence: deficits
in the adaptive immunity in the elderly. Tissue Antigens,
v. 70, n. 3, p. 179-189, 2007.
JANEWAY, C. et al. Immunobiology: The Immune System
in Health and Disease. 5 ed. New York: Garland Publishing,
732 p.
JOHNSON, S. A.; CAMBIER, J. C. Ageing, autoimmunity
and arthritis: Senescence of the B cell compartment –
implications for humoral immunity. Arthristis Research
& Therapy, v. 6, n. 4, p. 131-139, 2004.
MALAGUARNERA, L. et al. Immunosenescence: a review.
Archives in Gerontology and Geriatrics, v. 32, n.1, p.
-14, 2001.
OSTAN, R. et al. Immunosenescence and Immunogenetics
of Human Longevity. Neuroimmunomodulation, v. 15,
n. 4-6, p. 224-240, 2008.
PANDA, A., et al. Human innate immunosenescence:
causes and consequences for immunity in old age.
Trends in Immunology, v. 30, n. 7, p. 325-333, 2009.
PAWELEC, G.; LARBI, A. Immunity and ageing in man:
Annual review 2006/2007. Experimental Gerontology, v.
, n. 1, p. 34-37, 2008.
RYMKIEWICZ, P. et al. The Immune System in the Aging
Human. Immunologic Research, v. 73, n. 1-3, p. 235-250,
SHAW, A. C., et al. Aging of the Innate Immune System.
Current Opinion in Immunology, v. 22, n. 4, p. 507-513,
SOLANA, R. et al. Innate immunosenescence: Effect of
aging on cells and receptors of the innate immune system
in humans. Seminars in Immunology, v. 24, n. 5, p.
-241, 2012.